MitoEbselen-2 chloride
Code | Size | Price |
---|
TAR-T33407-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
MitoEbselen-2 is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to whole body γ-irradiation.
CAS:
1638973-78-0
Formula:
C35H30ClN2O2PSe
Molecular Weight:
656.03
Purity:
0.98
SMILES:
[Cl-].O=C(Cc1ccc(cc1)-n1[se]c2ccccc2c1=O)NCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1
References
Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bay?r H. Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator". ACS Med Chem Lett. 2016 Jun 1;7(6):653-4. doi: 10.1021/acsmedchemlett.6b00212. eCollection 2016 Jun 9. PubMed PMID: 27326344; PubMed Central PMCID: PMC4910416.
Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bay?r H. Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med Chem Lett. 2014 Nov 18;5(12):1304-1307. eCollection 2014 Dec 11. PubMed PMID: 25530831; PubMed Central PMCID: PMC4266336.