MK771
| Code | Size | Price |
|---|
| TAR-T33438-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33438-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33438-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MK771 is a therapeutic agent and an analog of the Thyrotropin Releasing Hormone (TRH). TRH and its analogs may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects.
CAS:
66537-55-1
Formula:
C16H22N6O4S
Molecular Weight:
394.45
Purity:
0.98
SMILES:
NC(=O)[C@H]1CSCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCC(=O)N1
References
Simasko SM, Horita A. Treatment of rats with the TRH analog MK-771. Down-regulation of TRH receptors and behavioral tolerance. Neuropharmacology. 1985 Feb;24(2):157-65. PubMed PMID: 2986033.
Hutson PH, Semark JE, Middlemiss DN. The TRH analogue MK-771, increases acetylcholine release in hippocampus but not striatum of the conscious rat. Neurosci Lett. 1990 Aug 14;116(1-2):149-55. PubMed PMID: 2124336.
Sills MA, Jacobowitz DM. Chronic administration of desipramine or nialamide decreases wet-dog shakes in rats produced by the TRH-analog MK-771. Brain Res. 1987 Jan 13;401(1):195-9. PubMed PMID: 3101979.
Horita A, Carino MA, Lai H. Preliminary studies on the effects of a TRH analog, MK-771, in an animal model of Alzheimer's disease. Proc West Pharmacol Soc. 1987;30:57-8. PubMed PMID: 3114755.