MK-912
| Code | Size | Price |
|---|
| TAR-T33444-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MK-912 is a potent novel selective alpha2-adrenergic receptor antagonist with oral activity to study the effect of short-term selective alpha2-blockers on fasting glucose (FPG) and islet function in non-insulin-dependent patients with diabetes mellitus (NIDDM).
CAS:
119942-70-0
Formula:
C20H26ClN3O2
Molecular Weight:
375.9
Purity:
0.98
SMILES:
Cl.[H][C@@]12C[C@@]3(CCN(C)C(=O)N3C)CCN1CCc1c2oc2ccccc12
References
Qin X, Frech P. Liquid chromatography/mass spectrometry (LC/MS) identification of photooxidative degradates of crystalline and amorphous MK-912. J Pharm Sci. 2001 Jul;90(7):833-44. PubMed PMID: 11458333.
Shiue C, Pleus RC, Shiue GG, Rysavy JA, Sunderland JJ, Cornish KG, Young SD, Bylund DB. Synthesis and biological evaluation of [11C]MK-912 as an alpha2-adrenergic receptor radioligand for PET studies. Nucl Med Biol. 1998 Feb;25(2):127-33. PubMed PMID: 9468027.
Uhl?n S, Xia Y, Chhajlani V, Felder CC, Wikberg JE. [3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor. Br J Pharmacol. 1992 Aug;106(4):986-95. Erratum in: Br J Pharmacol 1993 Mar;108(3):852. PubMed PMID: 1356570; PubMed Central PMCID: PMC1907663.
Ortiz-Alonso FJ, Herman WH, Gertz BJ, Williams VC, Smith MJ, Halter JB. Effect of an oral alpha 2-adrenergic blocker (MK-912) on pancreatic islet function in non-insulin-dependent diabetes mellitus. Metabolism. 1991 Nov;40(11):1160-7. PubMed PMID: 1682787.