MK-9470
| Code | Size | Price |
|---|
| TAR-T33446-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MK-9470 is a selective, high-affinity reverse agonist and is also a fluorine 18 labeled positron emission tomography (PET) radiotracer [(18) F]. The MK-9470 has been used to image cannabinoid receptor type 1 in healthy and ill human brains.
CAS:
947371-30-4
Formula:
C29H32FN3O3
Molecular Weight:
489.591
Purity:
0.98
SMILES:
C[C@H](NC(=O)C(C)(C)Oc1ccc(C)cn1)[C@@H](Cc1ccc(OCCF)cc1)c1cccc(c1)C#N
References
Ly HG, Ceccarini J, Weltens N, Bormans G, Van Laere K, Tack J, Van Oudenhove L. Increased cerebral cannabinoid-1 receptor availability is a stable feature of functional dyspepsia: a [F]MK-9470 PET study. Psychother Psychosom. 2015;84(3):149-58. doi: 10.1159/000375454. Epub 2015 Mar 28. PubMed PMID: 25833408.
Verdurand M, Dalton VS, Nguyen V, Gr?goire MC, Zahra D, Wyatt N, Burgess L, Greguric I, Zavitsanou K. Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: a longitudinal small animal PET study using [(18)F]MK-9470. Exp Neurol. 2014 Jul;257:162-9. doi: 10.1016/j.expneurol.2014.05.004. Epub 2014 May 10. PubMed PMID: 24825369.
Ceccarini J, Kuepper R, Kemels D, van Os J, Henquet C, Van Laere K. [18F]MK-9470 PET measurement of cannabinoid CB1 receptor availability in chronic cannabis users. Addict Biol. 2015 Mar;20(2):357-67. doi: 10.1111/adb.12116. Epub 2013 Dec 27. PubMed PMID: 24373053.
Thomae D, Morley TJ, Hamill T, Carroll VM, Papin C, Twardy NM, Lee HS, Hargreaves R, Baldwin RM, Tamagnan G, Alagille D. Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470. J Labelled Comp Radiopharm. 2014 Aug;57(10):611-4. doi: 10.1002/jlcr.3219. Epub 2014 Aug 25. PubMed PMID: 25156811.