Mnm5s2U
| Code | Size | Price |
|---|
| TAR-T33463-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Mnm5s2U is a hypermodified nucleoside.
CAS:
32860-54-1
Formula:
C11H17N3O5S
Molecular Weight:
303.33
Purity:
0.98
SMILES:
CNCc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=S)[nH]c1=O
References
Hagervall TG, Bj?rk GR. Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. Mol Gen Genet. 1984;196(2):201-7. PubMed PMID: 6387395.
Durant PC, Bajji AC, Sundaram M, Kumar RK, Davis DR. Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A. Biochemistry. 2005 Jun 7;44(22):8078-89. PubMed PMID: 15924427.
Pearson D, Carell T. Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U. Nucleic Acids Res. 2011 Jun;39(11):4818-26. doi: 10.1093/nar/gkr071. Epub 2011 Feb 8. PubMed PMID: 21306992; PubMed Central PMCID: PMC3113582.
Roovers M, Oudjama Y, Kaminska KH, Purta E, Caillet J, Droogmans L, Bujnicki JM. Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA. Proteins. 2008 Jun;71(4):2076-85. doi: 10.1002/prot.21918. PubMed PMID: 18186482.