MS 8209
| Code | Size | Price |
|---|
| TAR-T33509-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MS 8209 is an amphotericin B derivative has effects on on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages.
CAS:
136458-97-4
Formula:
C67H104N2O27
Molecular Weight:
1369.556
Purity:
0.98
SMILES:
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@H]1O[C@H](O[C@@H]2C[C@H]3O[C@@](O)(C[C@@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)C=CC=CC=CC=C/C=CC=CC=C/2)[C@@H](O)[C@@H](NCC(=O)[C@@H](O)[C@@H]2O[C@H](OC[C@H]2O)c2ccccc2)[C@@H]1O
References
Grigoriev VB, Adjou KT, Sal?s N, Simoneau S, Deslys JP, Seman M, Dormont D, Fournier JG. Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters. J Mol Neurosci. 2002 Jun;18(3):271-81. PubMed PMID: 12059046.
Adjou KT, Privat N, Demart S, Deslys JP, Seman M, Hauw JJ, Dormont D. MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters. J Comp Pathol. 2000 Jan;122(1):3-8. PubMed PMID: 10627386.
Clayette P, Martin M, Beringue V, Dereuddre-Bosquet N, Adjou KT, Seman M, Dormont D. Effects of MS-8209, an amphotericin B derivative, on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages. Antimicrob Agents Chemother. 2000 Feb;44(2):405-7. PubMed PMID: 10639370; PubMed Central PMCID: PMC89691.
Adjou KT, Demaimay R, Lasmezas C, Deslys JP, Seman M, Dormont D. MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie. Antimicrob Agents Chemother. 1995 Dec;39(12):2810-2. PubMed PMID: 8593027; PubMed Central PMCID: PMC163037.