Muzolimine
| Code | Size | Price |
|---|
| TAR-T33534-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33534-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
CAS:
55294-15-0
Formula:
C11H11Cl2N3O
Molecular Weight:
272.13
Purity:
0.98
SMILES:
CC(N1N=C(N)CC1=O)c1ccc(Cl)c(Cl)c1
References
Grima M, Michel B, Barthelmebs M, Stephan D, Imbs JL. The effects of muzolimine and urine from muzolimine-treated rats on Na+K+Cl- cotransport in Madin-Darby canine kidney cells. Eur J Pharmacol. 1991 Sep 17;202(2):137-42. PubMed PMID: 1802742.
Planelles G, Meilhac B, Anagnostopoulos T. Effects of muzolimine on the late distal tubule of necturus kidney. J Pharmacol Exp Ther. 1988 Sep;246(3):1152-7. PubMed PMID: 3418514.
Sastry CS, Suryanarayana MV, Tipirneni AS, Prasad TN. Spectrophotometric determination of muzolimine. Talanta. 1988 Nov;35(11):914-6. PubMed PMID: 18964644.
Pohlmann-Eden B, Berlit P, Maibach EA, Gretz N. Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases. Acta Neurol Scand. 1991 Jan;83(1):41-4. PubMed PMID: 1849334.