NLP 1
| Code | Size | Price |
|---|
| TAR-T33700-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33700-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33700-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NLP 1 is a DNA intercalating hypoxic cell radiosensitizer and cytotoxin.
CAS:
121064-77-5
Formula:
C19H17BrN4O2
Molecular Weight:
413.275
Purity:
0.98
SMILES:
[Br-].[O-][N+](=O)c1nccn1CCC[n+]1cc2ccccc2c2ccccc12
References
Cowan DS, McClelland RA, Rauth AM. Isolation and characterization of a cell line resistant to 5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide (2-NLP-3), a DNA-intercalating hypoxic cell radiosensitizer and cytotoxin. Biochem Pharmacol. 1995 Jun 29;50(1):61-8. PubMed PMID: 7605346.
Panicucci R, Heal R, Laderoute K, Cowan D, McClelland RA, Rauth AM. NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):1039-43. PubMed PMID: 2703383.
Cowan DS, Kanagasabapathy VM, McClelland RA, Rauth AM. Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation. Int J Radiat Oncol Biol Phys. 1992;22(3):541-4. PubMed PMID: 1735693.
Buchko GW, Weinfeld M. DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation. Radiat Res. 2002 Sep;158(3):302-10. PubMed PMID: 12175307.