Ono 4007
| Code | Size | Price |
|---|
| TAR-T33802-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ONO 4007 is a novel synthetic low-toxicity lipid A analog that stimulates the production of tumor necrosis factor-α in tumor tissues, resulting in the rejection of transplanted rat hepatocellular carcinoma cells. ONO-4007 has been shown to have a therapeutic effect in the treatment of TNF-α-sensitive tumors and tumor eradication.
CAS:
152646-95-2
Formula:
C50H78NNaO12S
Molecular Weight:
940.22
Purity:
0.98
SMILES:
[Na+].CCCCCCCCCCCC(CC(=O)NC(C=O)C(OC(=O)CCCCCCCCc1ccccc1)C(OS([O-])(=O)=O)C(O)CO)OC(=O)CCCCCCCCc1ccccc1
References
Khan MA, Maruno M, Khaskhely NM, Ramzi ST, Hosokawa A, Uezato H, Landires EA, Hashiguchi Y, Nonaka S. Inhibition of intracellular proliferation of Leishmania parasites in vitro and suppression of skin lesion development in BALB/c mice by a novel lipid A analog (ONO-4007). Am J Trop Med Hyg. 2002 Aug;67(2):184-90. PubMed PMID: 12389945.
Matsushita K, Kuramitsu Y, Ohiro Y, Kobayashi I, Watanabe T, Kobayashi M, Hosokawa M. ONO-4007, a synthetic lipid A analog, induces Th1-type immune response in tumor eradication and restores nitric oxide production by peritoneal macrophages. Int J Oncol. 2003 Aug;23(2):489-93. PubMed PMID: 12851700.
Saito Y, Kuramitsu Y, Arai H, Kato Y, Fujimoto M, Ita M, Hayatsu Y, Shinozaki F, Nakamura K. A signaling pathway by a new synthetic lipid A analog, ONO-4007, in RAW264.7 cells. Anticancer Drugs. 2002 Nov;13(10):1069-75. PubMed PMID: 12439341.
Calvopina M, Barroso PA, Marco JD, Korenaga M, Cooper PJ, Nonaka S, Hashiguchi Y. Efficacy of vaccination with a combination of Leishmania amastigote antigens and the lipid A-analogue ONO-4007 for immunoprophylaxis and immunotherapy against Leishmania amazonensis infection in a murine model of New World cutaneous leishmaniasis. Vaccine. 2006 Jul 7;24(27-28):5645-52. Epub 2006 Mar 29. PubMed PMID: 16621179.