PBB3

TargetMol
Product Code: TAR-T33890
Supplier: TargetMol
CodeSizePrice
TAR-T33890-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
PBB3 is a tau-specific PET tracer.
CAS:
1565796-97-5
Formula:
C17H15N3OS
Molecular Weight:
309.39
Purity:
0.98
SMILES:
CNc1ccc(C=CC=Cc2nc3ccc(O)cc3s2)cn1

References

Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M. Comparative in-vitro and in-vivo quantifications of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models. J Nucl Med. 2018 Feb 1. pii: jnumed.117.201632. doi: 10.2967/jnumed.117.201632. [Epub ahead of print] PubMed PMID: 29419480. Chiotis K, Stenkrona P, Almkvist O, Stepanov V, Ferreira D, Arakawa R, Takano A, Westman E, Varrone A, Okamura N, Shimada H, Higuchi M, Halldin C, Nordberg A. Dual tracer tau PET imaging reveals different molecular targets for (11)C-THK5351 and (11)C-PBB3 in the Alzheimer brain. Eur J Nucl Med Mol Imaging. 2018 May 12. doi: 10.1007/s00259-018-4012-5. [Epub ahead of print] PubMed PMID: 29752516. Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N. In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510. J Alzheimers Dis. 2018;61(3):1037-1052. doi: 10.3233/JAD-170509. PubMed PMID: 29332041. Murugan NA, Nordberg A, ?gren H. Different Positron Emission Tomography Tau Tracers Bind to Multiple Binding Sites on the Tau Fibril: Insight from Computational Modeling. ACS Chem Neurosci. 2018 May 2. doi: 10.1021/acschemneuro.8b00093. [Epub ahead of print] PubMed PMID: 29630333.