Glabridin
| Code | Size | Price |
|---|
| TAR-T3403-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3403-20mg | 20mg | £135.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3403-100mg | 100mg | £224.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
CAS:
59870-68-7
Formula:
C20H20O4
Molecular Weight:
324.376
Pathway:
NF-κb; Proteases/Proteasome; DNA Damage/DNA Repair; Neuroscience; Metabolism; Membrane transporter/Ion channel; Microbiology/Virology; Immunology/Inflammation
Purity:
0.9984
SMILES:
CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O
Target:
Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR
References
El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559.
Yokota Tm , et al. Pigment Cell Res. 1998 Dec;11(6):355-61.
Hsieh MJ, et al. Br J Pharmacol. 2014 Jun;171(12):3037-50.
Yehuda I, et al. Mol Nutr Food Res. 2015 Jun;59(6):1041-52.