Psilostachyin C
| Code | Size | Price |
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| TAR-T34180-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Psilostachyin c is a member of the class of compounds known as ambrosanolides and secoambrosanolides. Ambrosanolides and secoambrosanolides are sesquiterpene lactones from the Ambrosia family, with a backbone derivative of azuleno[6,5-b]furan-2-one (ambrosanolides) or azuleno[4,5-b]furan-2-one (secoambrosanolides). Psilostachyin c is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Psilostachyin c can be found in mugwort, which makes psilostachyin c a potential biomarker for the consumption of this food product.
CAS:
6466-67-7
Formula:
C15H20O4
Molecular Weight:
264.321
Purity:
0.98
SMILES:
C[C@@H]1CC[C@H]2[C@H](OC(=O)C2=C)[C@]2(C)OC(=O)CC[C@H]12
References
Martino R, Beer MF, Elso O, Donadel O, S?lsen V, Anesini C. Sesquiterpene lactones from Ambrosia spp. are active against a murine lymphoma cell line by inducing apoptosis and cell cycle arrest. Toxicol In Vitro. 2015 Oct;29(7):1529-36. doi: 10.1016/j.tiv.2015.06.011. Epub 2015 Jun 15. PubMed PMID: 26086122.
Barrera P, S?lsen VP, Lozano E, Rivera M, Beer MF, Tonn C, Martino VS, Sosa MA. Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana. Evid Based Complement Alternat Med. 2013;2013:163404. doi: 10.1155/2013/163404. Epub 2013 Jun 4. PubMed PMID: 23861697; PubMed Central PMCID: PMC3687511.
S?lsen VP, Puente V, Papademetrio D, Batlle A, Martino VS, Frank FM, Lombardo ME. Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi. PLoS One. 2016 Mar 3;11(3):e0150526. doi: 10.1371/journal.pone.0150526. eCollection 2016. PubMed PMID: 26939119; PubMed Central PMCID: PMC4777292.
S?lsen VP, Frank FM, Cazorla SI, Barrera P, Freixa B, Vila R, Sosa MA, Malchiodi EL, Muschietti LV, Martino VS. Psilostachyin C: a natural compound with trypanocidal activity. Int J Antimicrob Agents. 2011 Jun;37(6):536-43. doi: 10.1016/j.ijantimicag.2011.02.003. Epub 2011 Apr 15. PubMed PMID: 21497061.