Pulchellin
| Code | Size | Price |
|---|
| TAR-T34191-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pulchellin is a type-2 Ribosome Inactivating Protein (RIP), whose action mechanism proposed would be initiate by B-chain binding on glycoconjugate onto the cell surface (lectinic chain). pulchellin isoforms toxicity is the interaction between B-chain lectinic and the glycosyl residues on cell surface. pulchellin A chain is a novel of selective immunotoxin cytotoxicity.
CAS:
6754-35-4
Formula:
C15H22O4
Molecular Weight:
266.337
Purity:
0.98
SMILES:
C[C@@H]1C[C@@H]2OC(=O)C(=C)[C@H]2C[C@]2(C)[C@H](O)C[C@H](O)C12
References
Ivanova V, Trendafilova A, Todorova M, Danova K, Dimitrov D. Phytochemical Profile of Inula britannica from Bulgaria. Nat Prod Commun. 2017 Feb;12(2):153-154. PubMed PMID: 30428197.
Sadraeian M, Guimar?es FEG, Ara?jo APU, Worthylake DK, LeCour LJ, Pincus SH. Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope. Sci Rep. 2017 Aug 8;7(1):7579. doi: 10.1038/s41598-017-08037-3. PubMed PMID: 28790381; PubMed Central PMCID: PMC5548917.
Huang H, Niu J, Wang F, Hu L, Yu Q. A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2. Invest New Drugs. 2018 Aug 3. doi: 10.1007/s10637-018-0637-2. [Epub ahead of print] PubMed PMID: 30073465.
Xiao H, Rao Ravu R, Tekwani BL, Li W, Liu WB, Jacob MR, Khan SI, Cai X, Peng CY, Khan IA, Li XC, Wang W. Biological evaluation of phytoconstituents from Polygonum hydropiper. Nat Prod Res. 2017 Sep;31(17):2053-2057. doi: 10.1080/14786419.2016.1269094. Epub 2016 Dec 21. PubMed PMID: 28000515.