Pumiliotoxin C
| Code | Size | Price |
|---|
| TAR-T34192-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pumiliotoxins (PTXs), are one of several toxins found in the skin of poison dart frogs. There are three different types of this toxin: A, B and C, of which toxins A and B are more toxic than C. Pumiliotoxins interfere with muscle contraction by affecting calcium channels, causing partial paralysis, difficulty moving, hyperactivity, or death.
CAS:
27766-71-8
Formula:
C13H25N
Molecular Weight:
195.35
Purity:
0.98
SMILES:
CCC[C@H]1CC[C@H]2[C@H](C)CCC[C@@H]2N1
References
Suryavanshi PA, Sridharan V, Maiti S, Men?ndez JC. Fully diastereoselective synthesis of polysubstituted, functionalized piperidines and decahydroquinolines based on multicomponent reactions catalyzed by cerium(IV) ammonium nitrate. Chemistry. 2014 Jul 7;20(28):8791-9. doi: 10.1002/chem.201402607. Epub 2014 Jun 6. PubMed PMID: 24909665.
Dion I, Vincent-Rocan JF, Zhang L, Cebrowski PH, Lebrun ME, Pfeiffer JY, B?dard AC, Beauchemin AM. Studies on difficult intramolecular hydroaminations in the context of four syntheses of alkaloid natural products. J Org Chem. 2013 Dec 20;78(24):12735-49. doi: 10.1021/jo4023149. Epub 2013 Dec 4. PubMed PMID: 24274926.
Tarvin RD, Santos JC, O'Connell LA, Zakon HH, Cannatella DC. Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs. Mol Biol Evol. 2016 Apr;33(4):1068-81. doi: 10.1093/molbev/msv350. Epub 2016 Jan 18. PubMed PMID: 26782998.
Qu J, Helmchen G. Applications of Iridium-Catalyzed Asymmetric Allylic Substitution Reactions in Target-Oriented Synthesis. Acc Chem Res. 2017 Oct 17;50(10):2539-2555. doi: 10.1021/acs.accounts.7b00300. Epub 2017 Sep 22. PubMed PMID: 28937739.