RS-0406
| Code | Size | Price |
|---|
| TAR-T34418-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34418-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34418-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
RS-0406 is a new type of β-flakes blocker, which can reverse amyloid β-induced cytotoxicity and long-term enhanced damage in vitro, and inhibit amyloid-oligomer-induced behavior deterioration in vivo.
CAS:
530112-00-6
Formula:
C16H14N4O2
Molecular Weight:
294.314
Purity:
0.98
SMILES:
Oc1cccc(Nc2ccc(Nc3cccc(O)c3)nn2)c1
References
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 9;25(10):2455-62. Erratum in: J Neurosci. 2005 May 4;25(18):4658. PubMed PMID: 15758153.
O'Hare E, Scopes DI, Treherne JM, Norwood K, Spanswick D, Kim EM. RS-0406 arrests amyloid-beta oligomer-induced behavioural deterioration in vivo. Behav Brain Res. 2010 Jun 26;210(1):32-7. doi: 10.1016/j.bbr.2010.01.044. Epub 2010 Feb 5. PubMed PMID: 20138088.
Kalhor HR, Jabbari MP. Inhibition Mechanisms of a Pyridazine-Based Amyloid Inhibitor: As a ?-Sheet Destabilizer and a Helix Bridge Maker. J Phys Chem B. 2017 Aug 17;121(32):7633-7645. doi: 10.1021/acs.jpcb.7b05189. Epub 2017 Aug 3. PubMed PMID: 28771005.
Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM. A? oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br J Pharmacol. 2012 Sep;167(2):383-92. doi: 10.1111/j.1476-5381.2012.01973.x. PubMed PMID: 22913627; PubMed Central PMCID: PMC3481045.