Ryanodol
| Code | Size | Price |
|---|
| TAR-T34458-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
CAS:
6688-49-9
Formula:
C20H32O8
Molecular Weight:
400.468
Purity:
0.98
SMILES:
CC(C)[C@@]1(O)[C@@H](O)[C@@]2(O)[C@@]3(C)C[C@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@]14C
References
Masuda K, Nagatomo M, Inoue M. Chemical Conversion of Ryanodol to Ryanodine. Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):874-9. doi: 10.1248/cpb.c16-00214. Epub 2016 Mar 23. PubMed PMID: 27010543.
Chuang KV, Xu C, Reisman SE. A 15-step synthesis of (+)-ryanodol. Science. 2016 Aug 26;353(6302):912-5. doi: 10.1126/science.aag1028. PubMed PMID: 27563092; PubMed Central PMCID: PMC5505075.
Nagatomo M, Koshimizu M, Masuda K, Tabuchi T, Urabe D, Inoue M. Total synthesis of ryanodol. J Am Chem Soc. 2014 Apr 23;136(16):5916-9. doi: 10.1021/ja502770n. Epub 2014 Apr 11. PubMed PMID: 24708178.
Masuda K, Koshimizu M, Nagatomo M, Inoue M. Asymmetric Total Synthesis of (+)-Ryanodol and (+)-Ryanodine. Chemistry. 2016 Jan 4;22(1):230-6. doi: 10.1002/chem.201503641. Epub 2015 Nov 30. PubMed PMID: 26616265.