Setileuton

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TargetMol
Product Code: TAR-T34624
Supplier: TargetMol
CodeSizePrice
TAR-T34624-1mg1mg£335.00
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TAR-T34624-5mg5mg£711.00
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TAR-T34624-1mL1 mL * 10 mM (in DMSO)£870.00
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TAR-T34624-10mg10mg£946.00
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TAR-T34624-25mg25mg£1,396.00
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TAR-T34624-50mg50mg£1,862.00
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TAR-T34624-100mg100mg£2,424.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Setileuton ( MK0633) is an effective and selective 5-lipoxygenase inhibitor being studied for the treatment of asthma and atherosclerosis.
CAS:
910656-27-8
Formula:
C22H17F4N3O4
Molecular Weight:
463.389
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC[C@](O)(c1nnc(NCc2ccc3c(cc(=O)oc3c2)-c2ccc(F)cc2)o1)C(F)(F)F
Target:
Lipoxygenase

References

Maciolek CM, et al. Novel cytochrome P450-mediated ring opening of the 1,3,4-oxadiazole in setileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2011 May;39(5):763-70. Ducharme Y, et al. The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1(4):170-4.