SL-017
| Code | Size | Price |
|---|
| TAR-T34657-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SL-017 (ACP-SL-017, ACPSL-017, ACP-SL-017) is a Hypocrellin-B (Hb) derivative and photosensitization agent that may be used to treat abnormal hair growth. SL017 targets the mitochondria and causes the mitochondrial membrane potential to collapse, producing ROS, which in turn leads to mitochondrial rupture.
CAS:
1169831-01-9
Formula:
C34H34N2O8
Molecular Weight:
598.652
Purity:
0.98
SMILES:
COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c1c(C(C(C)=O)C(C)=Cc(c(NCCCN(C)C)c2=O)c31)c(OC)c4=O
References
El-Sikhry HE, Miller GG, Madiyalakan MR, Seubert JM. Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid. Invest New Drugs. 2011 Dec;29(6):1328-36. doi: 10.1007/s10637-010-9495-2. Epub 2010 Jul 30. PubMed PMID: 20676746.