STAD 2
| Code | Size | Price |
|---|
| TAR-T34711-5mg | 5mg | £497.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap
CAS:
1542100-77-5
Formula:
C102H182N24O22
Molecular Weight:
2096.724
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@]1(C)CCCC=CCCC[C@](C)(NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)COCCOCCOCCN)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CCCCN)C(N)=O
References
Bendzunas NG, D?rfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg Med Chem. 2018 Mar 15;26(6):1174-1178. doi: 10.1016/j.bmc.2018.02.001. Epub 2018 Feb 12. PubMed PMID: 29449124; PubMed Central PMCID: PMC5844854.
Flaherty BR, Wang Y, Trope EC, Ho TG, Muralidharan V, Kennedy EJ, Peterson DS. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. PLoS One. 2015 May 26;10(5):e0129239. doi: 10.1371/journal.pone.0129239. eCollection 2015. PubMed PMID: 26010880; PubMed Central PMCID: PMC4444124.
Autenrieth K, Bendzunas NG, Bertinetti D Dr, Herberg FW Prof Dr, Kennedy EJ Prof Dr. Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI). Chembiochem. 2016 Apr 15;17(8):693-697. doi: 10.1002/cbic.201500632. Epub 2015 Dec 17. PubMed PMID: 26611881; PubMed Central PMCID: PMC4836982.