TAPAP
| Code | Size | Price |
|---|
| TAR-T34785-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
TAPAP binds to thrombin and trypsin.
CAS:
73438-63-8
Formula:
C22H28N4O3S
Molecular Weight:
428.55
Purity:
0.98
SMILES:
Cc1ccc(cc1)S(=O)(=O)NC(Cc1cccc(c1)C(N)=N)C(=O)N1CCCCC1
References
Turk D, St?rzebecher J, Bode W. Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes. FEBS Lett. 1991 Aug 5;287(1-2):133-8. PubMed PMID: 1879520.
Bergner A, Bauer M, Brandstetter H, St?rzebecher J, Bode W. The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity. J Enzyme Inhib. 1995;9(1):101-10. PubMed PMID: 8568562.
Zes?awska E, Jacob U, St?rzebecher J, Oleksyn BJ. The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate. Bioorg Med Chem Lett. 2006 Jan 1;16(1):228-34. Epub 2005 Oct 3. PubMed PMID: 16202591.
Hauptmann J, Markwardt F, Richter M. [Animal experiments on the pharmacokinetics of N alpha-tosyl-(3-amidinophenyl)alanine piperidide (TAPAP), a new thrombin inhibitor]. Pharmazie. 1982 Jun;37(6):430-3. German. PubMed PMID: 7122685.