Terrein
| Code | Size | Price |
|---|
| TAR-T34811-5mg | 5mg | £484.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34811-10mg | 10mg | £784.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.
CAS:
582-46-7
Formula:
C8H10O3
Molecular Weight:
154.165
Purity:
0.98
SMILES:
CC=CC1=CC(=O)[C@H](O)[C@H]1O
References
Zaehle C, Gressler M, Shelest E, Geib E, Hertweck C, Brock M. Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity. Chem Biol. 2014 Jun 19;21(6):719-31. doi: 10.1016/j.chembiol.2014.03.010. Epub 2014 May 8. PubMed PMID: 24816227.
Lee YH, Lee SJ, Jung JE, Kim JS, Lee NH, Yi HK. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. Cell Biochem Funct. 2015 Oct;33(7):479-86. doi: 10.1002/cbf.3145. Epub 2015 Sep 28. PubMed PMID: 26416516.
Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S. Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. Bioorg Med Chem. 2014 Oct 1;22(19):5338-44. doi: 10.1016/j.bmc.2014.07.047. Epub 2014 Aug 7. PubMed PMID: 25151086.
Yin Y, Xu B, Li Z, Zhang B. Enhanced production of (+)-terrein in fed-batch cultivation of Aspergillus terreus strain PF26 with sodium citrate. World J Microbiol Biotechnol. 2013 Mar;29(3):441-6. doi: 10.1007/s11274-012-1196-x. Epub 2012 Oct 21. PubMed PMID: 23085955.