TH9402
| Code | Size | Price |
|---|
| TAR-T34833-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
TH9402 is a dibrominated rhodamine derivative and potent photosensitizer and useful in photodynamic therapy. TH9402 eradicates multiple myeloma (MM) and BC cell lines, while sparing more than 50% of normal pluripotential blood stem cells from healthy volunteers. TH9402 offers an excellent potential as an ex vivo photodynamic purging agent for autologous transplantation in MM and BC treatment.
CAS:
174230-05-8
Formula:
C21H15Br2ClN2O3
Molecular Weight:
538.62
Purity:
0.98
SMILES:
[Cl-].COC(=O)c1ccccc1-c1c2ccc(N)c(Br)c2[o+]c2c(Br)c(N)ccc12
References
Tregs served sunny-side up By Betts, Brian C.; Young, James W. From Blood (2010), 116(23), 4736-4737.
Quaternized phthalocyanines and method for photodisinfection of water By Vorozhtsov, G. N.; Kaliya, O. L.; Kuznetsova, N. A.; Luzhkov, Yu. M.; Luk'yanets, E. A.; Makarov, D. A.; Negrimovskii, V. M.; Slivka, L. K.; Yuzhakova, O. A. From Russ. (2006), RU 2281953 C1 20060820.
Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation By Perruccio, Katia; Topini, Fabiana; Tosti, Antonella; Carotti, Alessandra; Aloisi, Teresa; Aversa, Franco; Martelli, Massimo F.; Velardi, Andrea From Blood Cells, Molecules, & Diseases (2008), 40(1), 76-83.
A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique By Mielke, Stephan; Nunes, Raquel; Rezvani, Katayoun; Fellowes, Vicki S.; Venne, Annie; Solomon, Scott R.; Fan, Yong; Gostick, Emma; Price, David A.; Scotto, Christian; et al From Blood (2008), 111(8), 4392-4402.