TargetMol

TM608

Product Code:
 
TAR-T34892
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34892-5mg5mg£850.00
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Further Information

Bioactivity:
TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial portions).
CAS:
1956343-52-4
Formula:
C43H37BrCl2N3O4PS
Molecular Weight:
873.62
Purity:
0.98
SMILES:
[Br-].Cc1[nH]c(C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)NCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1

References

Mitochondrial-Targeting MET Kinase Inhibitor Kills Erlotinib-Resistant Lung Cancer Cells Tianming Yang, Wai Har Ng, Huan Chen, Kamon Chomchopbun, The Hung Huynh, Mei Lin Go, and Oi Lian Kon Publication Date (Web): June 23, 2016 (Letter) doi: 10.1021/acsmedchemlett.6b00223