Ukrain
| Code | Size | Price |
|---|
| TAR-T34996-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ukrain, also known as NSC-631570, is claimed to be a semisynthetic compound of thiophosphoric acid (triaziridide) and the alkaloid chelidonine derived from the common weed, Chelidonium majus (greater celandine), which grows primarily in Europe and Asia.
CAS:
138069-52-0
Formula:
C66H75N6O18PS
Molecular Weight:
1303.38
Purity:
0.98
SMILES:
[OH-].[OH-].[OH-].[H][C@@]12[C@@H](O)Cc3cc4OCOc4cc3[C@@]1([H])[N@+](C)(CCNP(=S)(NCC[N@@+]1(C)Cc3c4OCOc4ccc3[C@@]3([H])[C@@H](O)Cc4cc5OCOc5cc4[C@@]13[H])NCC[N@@+]1(C)Cc3c4OCOc4ccc3[C@@]3([H])[C@@H](O)Cc4cc5OCOc5cc4[C@@]13[H])Cc1c3OCOc3ccc21
References
Venkatesh K, Govindaraj S, Ramachandran A, Kalimuthu S, Perumal E, Velayutham S, Jagadeesan A. Effect of ukrain on cell survival and apoptosis in the androgen-independent prostate cancer cell line PC-3. J Environ Pathol Toxicol Oncol. 2011;30(1):11-9. PubMed PMID: 21609312.
Gagliano N, Pettinari L, Aureli M, Martinelli C, Colombo E, Costa F, Carminati R, Volpari T, Colombo G, Milzani A, Dalle-Donne I, Gioia M. Malignant phenotype of renal cell carcinoma cells is switched by ukrain administration in vitro. Anticancer Drugs. 2011 Sep;22(8):749-62. doi: 10.1097/CAD.0b013e328346c7f7. PubMed PMID: 21799470.
Bozeman EN, Srivatsan S, Mohammadi H, Daniels D, Shashidharamurthy R, Selvaraj P. Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice. Exp Oncol. 2012 Dec;34(4):340-7. PubMed PMID: 23302993.
Gagliano N, Volpari T, Clerici M, Pettinari L, Barajon I, Portinaro N, Colombo G, Milzani A, Dalle-Donne I, Martinelli C. Pancreatic cancer cells retain the epithelial-related phenotype and modify mitotic spindle microtubules after the administration of ukrain in vitro. Anticancer Drugs. 2012 Oct;23(9):935-46. doi: 10.1097/CAD.0b013e32835507bc. PubMed PMID: 22700003.