X 910279
| Code | Size | Price |
|---|
| TAR-T35150-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
X 910279 is a leflunomide analog and a malononitrilamide.
CAS:
185915-32-6
Formula:
C14H11N3O2
Molecular Weight:
253.261
Purity:
0.98
SMILES:
O=C(Nc1ccc(cc1)C#N)C(C#N)C(=O)C1CC1
References
Schorlemmer HU, Kurrle R, Schleyerbach R, Bartlett RR. Disease-modifying activity of malononitrilamides, derivatives of leflunomide's active metabolite, on models of rheumatoid arthritis. Inflamm Res. 1999 Dec;48 Suppl 2:S113-4. PubMed PMID: 10667840.
Schorlemmer HU, Bartlett RR, Lindner JK, Kurrle R. Coadministration of malononitrilamides and tacrolimus induces tolerance in a rat skin allograft model. Transplant Proc. 1999 Feb-Mar;31(1-2):1184-8. PubMed PMID: 10083529.
Schorlemmer HU, Bartlett RR, Schleyerbach R. Immunomodulatory activity of malononitrilamides, derivatives of leflunomide's primary metabolite, on models of experimental rheumatoid arthritis. Transplant Proc. 1998 Dec;30(8):4137-9. PubMed PMID: 9865326.
Slauson SD, Silva HT, Sherwood SW, Morris RE. Flow cytometric analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide analogues in a novel whole blood assay. Immunol Lett. 1999 Apr 15;67(3):179-83. PubMed PMID: 10369124.