MitoTEMPO hydrate
| Code | Size | Price |
|---|
| TAR-T35964-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T35964-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T35964-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species.[2][3][4]
CAS:
1569257-94-8
Formula:
C29H37ClN2O3P
Molecular Weight:
528.05
Purity:
0.98
SMILES:
O.[Cl-].CC1(C)CC(CC(C)(C)N1[O])NC(=O)C[P+](c1ccccc1)(c1ccccc1)c1ccccc1
References
Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology & Medicine 51(7), 1289-1301 (2011).
Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009).
Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research 107(1), 106-116 (2010).
Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology & Medicine 49(10), 1550-1560 (2010). Product Citations