15-LOX-1 inhibitor 1
| Code | Size | Price |
|---|
| TAR-T36169-5mg | 5mg | £332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.
CAS:
2349374-37-2
Formula:
C22H21ClN2O4
Molecular Weight:
412.9
Purity:
0.98
SMILES:
ClC1=CC=C2C(NC(C(OCC)=O)=C2/C=C/C(NCC3=CC=CC=C3OC)=O)=C1
References
Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity. J. Med. Chem. 62(9), 4624-4637 (2019).