TargetMol

Becatecarin

Product Code:
 
TAR-T36485
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T36485-5mg5mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
CAS:
119673-08-4
Formula:
C33H34Cl2N4O7
Molecular Weight:
669.6
Purity:
0.98
SMILES:
O=C(N(CCN(CC)CC)C1=O)C2=C1C(C(C=CC=C3Cl)=C3N4[C@@H]5O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]5O)=C4C6=C2C7=C(C(Cl)=CC=C7)N6