Isoallolithocholic acid
| Code | Size | Price |
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| TAR-T36522-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T36522-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.[1],[2] It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).[1] AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.[2]
CAS:
2276-93-9
Formula:
C24H40O3
Molecular Weight:
376.6
Purity:
0.98
SMILES:
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
References
Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate ?1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008)
Vonk, R.J., Tuchweber, B., Mass?, D., et al.Intrahepatic cholestasis induced by allo monohydroxy bile acid in ratsGastroenterology80(2)242-249(1981)