TargetMol

IL-4-inhibitor-1

Product Code:
 
TAR-T36527
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36527-1mg1mg£102.00
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TAR-T36527-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T36527-5mg5mg£219.00
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TAR-T36527-10mg10mg£349.00
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TAR-T36527-25mg25mg£544.00
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TAR-T36527-50mg50mg£747.00
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Quantity:
TAR-T36527-100mg100mg£1,002.00
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This product comes from: United States.
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Further Information

Bioactivity:
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
CAS:
1332184-63-0
Formula:
C18H12FN3O2
Molecular Weight:
321.3
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
N#CC1=C(N)N=C(C2=CC=C(F)C=C2)C=C1C3=CC(O)=C(O)C=C3
Target:
IL Receptor

References

Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)