9-Methoxyellipticine
| Code | Size | Price |
|---|
| TAR-T36699-5mg | 5mg | £1,264.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine that has been found in O. maculataand has anticancer activity.It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 μM, respectively).
CAS:
10371-86-5
Formula:
C18H16N2O
Molecular Weight:
276.339
Purity:
0.98
SMILES:
COc1ccc2[nH]c3c(C)c4ccncc4c(C)c3c2c1
References
Vend?me, J., Letard, S., Martin, F., et al.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinasesJ. Med. Chem.48(20)6194-6201(2005)
Svoboda, G.H., Poore, G.A., and Montfort, M.L.Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). Isolation of the alkaloids and study of the antitumor properties of 9-methoxyellipticineJ. Pharm. Sci.57(10)1720-1725(1968)
Festy, B., Poisson, J., and Paoletti, C.A new DNA intercalating drug: Methoxy-9-ellipticineFEBS Lett.17(2)321-323(1971)