Reveromycin A
| Code | Size | Price |
|---|
| TAR-T37008-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in osteoclasts with an IC50 value of 0.7 μM.
CAS:
134615-37-5
Formula:
C36H52O11
Molecular Weight:
660.801
Purity:
0.98
SMILES:
CCCC[C@]1(CC[C@]2(CC[C@H](C)[C@@H](CC=C(/C)C=C[C@H](O)[C@@H](C)C=CC(O)=O)O2)O[C@H]1C=CC(C)=CC(O)=O)OC(=O)CCC(O)=O