TargetMol

N1-Acetylspermidine hydrochloride

Product Code:
 
TAR-T37170
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37170-1mg1mg£138.00
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TAR-T37170-5mg5mg£229.00
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TAR-T37170-10mg10mg£334.00
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TAR-T37170-25mg25mg£519.00
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TAR-T37170-50mg50mg£703.00
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TAR-T37170-100mg100mg£970.00
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Quantity:
TAR-T37170-500mg500mg£1,862.00
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Further Information

Bioactivity:
N1-Acetylspermidine is an acetyl derivative of spermidine that acts as a substrate for polyamine oxidase (PAO).1 In peroxisomes, PAO oxidizes N1-acetylspermidine to 3-acetamidopropanal and putrescine, a positively charged polyamine that binds DNA and is involved in various cellular processes including cell division, differentiation, and membrane function.2,3,4,5 N1-Acetylspermidine has been used to examine the interaction between DNA and polyamines during the cleavage of phosphodiester bonds at apurinic/apyrimidinic sites in DNA.6
CAS:
34450-16-3
Formula:
C9H23Cl2N3O
Molecular Weight:
260.2
Pathway:
Metabolism
Purity:
0.98
SMILES:
Cl.Cl.CC(=O)NCCCNCCCCN
Target:
Endogenous Metabolite

References

Gawandi, V., and Fitzpatrick, P.F. The synthesis of deuterium-labeled spermine, N1-acetylspermine and N1-acetylspermidine. Journal of Labelled Compounds and Radiopharmaceuticals 50(7), 666-670 (2007). Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. Haukanes, B.I., Szajko, K., and Helland, D.E. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. FEBS Letters 269(2), 389-393 (1990). Takao, K., Sugita, Y., and Shirahata, A. Assay of N1-acetylpolyamine oxidase activity with N1,N11-didansylnorspermine as the substrate by ion-pair reversed phase high performance liquid chromatography. Biological and Pharmaceutical Bullentin 33(7), 1089-1094 (2010).