TargetMol

Kigamicin C

Product Code:
 
TAR-T37844
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37844-5mg5mg£2,414.00
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This product comes from: United States.
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Further Information

Bioactivity:
Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).
CAS:
680571-51-1
Formula:
C41H47NO16
Molecular Weight:
809.8
Purity:
0.98
SMILES:
O=C1C2=C([C@@H](O)[C@H](O[C@]3([H])O[C@H](C)[C@@H](O[C@@]4([H])C[C@@H](OC)[C@H](O)[C@@H](C)O4)CC3)C[C@@H]2O)OC(C1=C5O)=C6OCO[C@@]7([H])C6=C5C(C(O)=C(C(N(CCO8)[C@@]8(C)C9)=O)C9=C%10)=C%10C7