2F-Peracetyl-Fucose
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
2F-Peracetyl-fucose is an inhibitor of protein fucosylation.[1] It inhibits fucosylation of IgG1 monoclonal antibodies produced by CHO-DG44 cells when used at a concentration of 50 µM. It reduces intracellular GDP-fucose levels in CHO-DG44 cells in a concentration-dependent manner. 2F-Peracetyl-fucose (100 µM) also decreases intracellular fucose levels in A. thaliana seedlings.[2] 2F-Peracetyl-fucose decreases root length in A. thaliana seedlings in a concentration-dependent manner.
CAS:
188783-78-0
Formula:
C12H17FO7
Molecular Weight:
292.3
Purity:
0.98
SMILES:
O=C(C)O[C@@H]([C@H]([C@@H]1F)OC(C)=O)[C@@H](OC1OC(C)=O)C
References
Villalobos, J.A., Yi, B.R., and Wallace, I.S.2-Fluoro-L-fucose is a metabolically incorporated inhibitor of plant cell wall polysaccharide fucosylationPLoS One10(9)e0139091(2015)
Okeley, N.M., Alley, S.C., Anderson, M.E., et al.Development of orally active inhibitors of protein and cellular fucosylationProc. Natl. Acad. Sci. USA110(14)5404-5409(2013)