HG-7-85-01
| Code | Size | Price |
|---|
| TAR-T38653-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl , PDGFRα , Kit , and Src kinases . HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase , KDR and RET with IC 50 s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC 50 >2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis , and inhibition of cell-cycle progression.
CAS:
1258391-13-7
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Ellen Weisberg, et al. Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of BCR-ABL, PDGFRalpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood. 2010 May 27;115(21):4206-16.