HBDDE

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TargetMol
Product Code: TAR-T39030
Supplier: TargetMol
CodeSizePrice
TAR-T39030-1mg1mg£352.00
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TAR-T39030-5mg5mg£736.00
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TAR-T39030-10mg10mg£978.00
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Quantity:
TAR-T39030-25mg25mg£1,348.00
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Quantity:
TAR-T39030-50mg50mg£1,661.00
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Quantity:
TAR-T39030-100mg100mg£2,079.00
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Quantity:
TAR-T39030-500mg500mg£4,006.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC 50 s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
CAS:
154675-18-0
Formula:
0
Molecular Weight:
0
Pathway:
Apoptosis|Cytoskeletal Signaling|Chromatin/Epigenetic
Purity:
0.98
SMILES:
0
Target:
Apoptosis|PKC

References

A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200.