TargetMol

PI3Kδ-IN-8

Product Code:
 
TAR-T39542
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39542-5mg5mg£850.00
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Further Information

Bioactivity:
PI3Kδ-IN-8 is a potent, selective and orally active PI3Kδ inhibitor, with an IC 50 of 3.3 nM. PI3Kδ-IN-8 shows selectivity for PI3Kδ over PI3Kα , PI3Kβ , and PI3Kγ ( IC 50 =377.2, 241.6, 17.9 nM, respectively). PI3Kδ-IN-8 has anti-tumor activity.
CAS:
2101518-75-4
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Shukla MR, et, al. Discovery of a Potent and Selective PI3K? Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models. J. Med. Chem. 2020 Dec 1.