AP14145 hydrochloride
| Code | Size | Price |
|---|
| TAR-T39963-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
AP14145 hydrochloride is a potent K Ca 2 (SK) channel negative allosteric modulator with an IC 50 of 1.1 μM for K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF).
CAS:
2387505-59-9
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Jonas Goldin Diness, et al. Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca 2+ -Activated K + Channels in Pigs. Circ Arrhythm Electrophysiol. 2017 Oct;10(10):e005125.
Rafel Sim?-Vicens, et al. A New Negative Allosteric Modulator, AP14145, for the Study of Small Conductance Calcium-Activated Potassium (K Ca 2) Channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408.