RET-IN-4
| Code | Size | Price |
|---|
| TAR-T40097-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
RET-IN-4 is a potent, selective and orally active RET inhibitor with IC 50 s of 1.29 nM, 1.97 nM, and 0.99 nM for RET (WT) , RET (V804M) , and RET (M918T) , respectively. RET-IN-4 exhibits better kinases selectivity against JAK2 (IC 50 of 4.4 nM) and FLT3 (IC 50 of 30.8 nM). RET-IN-4 has anticancer effects.
CAS:
2436473-55-9
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Zhibo Luo, et al. Discovery and Optimization of Selective RET Inhibitors via Scaffold Hopping. Bioorg Med Chem Lett. 2021 May 28;128149.