Ziritaxestat
Code | Size | Price |
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TAR-T4041-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-1mL | 1 mL * 10 mM (in DMSO) | £115.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-10mg | 10mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-25mg | 25mg | £168.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-50mg | 50mg | £230.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-100mg | 100mg | £367.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4041-200mg | 200mg | £511.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
CAS:
1628260-79-6
Formula:
C30H33FN8O2S
Molecular Weight:
588.71
Pathway:
Metabolism
Purity:
0.9967
SMILES:
CCc1nc2c(C)cc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1
Target:
PDE
References
Yang Y, Zhang X, Zhang X, et al. Modulators of histone demethylase JMJD1C selectively target leukemic stem cells[J]. FEBS Open Bio. 2020
Yang Y, Zhang X, Zhang X, et al. Modulators of histone demethylase JMJD1C selectively target leukemic stem cells. FEBS Open Bio. 2020
Chen J, Guan Z, Dong N, et al. A novel LC?MS/MS method for the determination of ziritaxestat in rat plasma and its pharmacokinetic study[J]. Biomedical Chromatography. 2020: e4863.
Desroy N., et al. Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinicalal Evaluation for the Treatment of Idiopathic PulmoN/Ary Fibrosis. J Med Chem. 2017 May 11;60(9):3580-3590.
Balupuri A., et al. Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors. Bioorg Med Chem Lett. 2017 Jul 16. pii: S0960-894X(17)30718-7.
Chen J, Guan Z, Dong N, et al. A novel LC?MS/MS method for the determination of ziritaxestat in rat plasma and its pharmacokinetic study[J]. Biomedical Chromatography. 2020: e4863.
Chen J, Guan Z, Dong N, et al. A novel LC?MS/MS method for the determination of ziritaxestat in rat plasma and its pharmacokinetic study. Biomedical Chromatography. 2020: e4863.