MLS1082
| Code | Size | Price |
|---|
| TAR-T41014-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC 50 of 123 nM for DA-stimulated G protein signaling.
CAS:
883958-36-9
Formula:
C24H23N3O2
Molecular Weight:
385.467
Purity:
0.98
SMILES:
Cn1c2ccccc2c(=O)c2c1nc(C1CCCCC1)n(-c1ccccc1)c2=O
References
Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209.
Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.