P53R3

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TargetMol
Product Code: TAR-T41068
Supplier: TargetMol
CodeSizePrice
TAR-T41068-1mg1mg£163.00
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TAR-T41068-5mg5mg£303.00
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TAR-T41068-10mg10mg£418.00
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TAR-T41068-25mg25mg£646.00
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TAR-T41068-50mg50mg£863.00
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TAR-T41068-100mg100mg£1,171.00
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TAR-T41068-500mg500mg£2,263.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 R175H , p53 R248W and p53 R273H . P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5) . P53R3 is used for cancer research.
CAS:
922150-12-7
Formula:
0
Molecular Weight:
0
Pathway:
Apoptosis
Purity:
0.98
SMILES:
0
Target:
p53

References

Alejandro Parrales, et al. Targeting Oncogenic Mutant p53 for Cancer Therapy. Front Oncol