TargetMol

Auraptene

Product Code:
 
TAR-T4115
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4115-5mg5mg£95.00
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TAR-T4115-10mg10mg£102.00
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TAR-T4115-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4115-25mg25mg£118.00
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TAR-T4115-50mg50mg£132.00
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TAR-T4115-100mg100mg£182.00
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TAR-T4115-500mg500mg£343.00
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Further Information

Bioactivity:
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.
CAS:
495-02-3
Formula:
C19H22O3
Molecular Weight:
298.382
Pathway:
Proteases/Proteasome; Neuroscience
Purity:
0.98
SMILES:
CC(C)=CCCC(C)=CCOc1ccc2ccc(=O)oc2c1
Target:
MMP; BACE

References

Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21(10), 1843-1850 (2000). Furukawa, Y.,Watanabe, S.,Okuyama, S., et al. Neurotrophic effect of Citrus auraptene: Neuritogenic activity in PC12 cells.International Journal of Molecular Sciences 13,5338-5347(2012). Takeda, K.,Utsunomiya, H.,Kakiuchi, S.,et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.J.Oleo Sci.56(5),253-260(2007). Krishnan, P.,Yan, K.J.,Windler, D.,et al.Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.BMC Cancer9,(2009). Sahebkar, A.Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease.Ann.Hepatol.10(4),575-577(2011).