NCT-503

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TargetMol
Product Code: TAR-T4213
Supplier: TargetMol
CodeSizePrice
TAR-T4213-2mg2mg£99.00
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TAR-T4213-5mg5mg£116.00
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TAR-T4213-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T4213-10mg10mg£144.00
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TAR-T4213-25mg25mg£229.00
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TAR-T4213-50mg50mg£357.00
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TAR-T4213-100mg100mg£542.00
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TAR-T4213-200mg200mg£691.00
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TAR-T4213-500mg500mg£1,026.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
CAS:
1916571-90-8
Formula:
C20H23F3N4S
Molecular Weight:
408.49
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Metabolism
Purity:
0.9956
SMILES:
Cc1cc(C)nc(NC(=S)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c1
Target:
Dehydrogenase; FLT; TAM Receptor

References

Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. Chen H, Liu C, Wang Q, et al. Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver. Nature Communications. 2022, 13(1): 1-19