ML385

Shi B, Hao Y, Li W, et al. TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage?Related Neutrophilic Inflammation in Asthma. Frontiers in Immunology. 2022, 13 Wu Y, Wang Y, Gao Z, et al. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. Acta Pharmacologica Sinica. 2021, 42(12): 2069-2081. Chen W, Ye Y, Wu Z, et al. Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells. Oxidative Medicine and Cellular Longevity. 2021, 2021. Xue J, Liao Q, Luo M, et al. Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation. Open Biology. 2022, 12(4): 210310 Li X, Qin X, Tian J, et al. Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-?B pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway. Food and Chemical Toxicology. 2020: 111801 Wen H, Zhang X, Li Q, et al. Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway. Oxidative Medicine and Cellular Longevity. 2022 Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Frontiers in Immunology. 2020 Dec 7;11:580593. doi: 10.3389 Zhang Q, Bai X, Wang R, et al. 4?octyl Itaconate inhibits lipopolysaccharide (LPS)?induced osteoarthritis via activating Nrf2 signalling pathway. Journal of Cellular and Molecular Medicine. 2022 Lan J, Zhou Y, Wang H, et al.Protective Effect of Human Umbilical Cord Mesenchymal Stem Cell Derived Conditioned Medium in a Mutant TDP-43 Induced Motoneuron-Like Cellular Model of ALS.Brain Research Bulletin.2022 Chen X, Liang H, Xi Z, et al. BM-MSC Transplantation Alleviates Intracerebral Hemorrhage-Induced Brain Injury, Promotes Astrocytes Vimentin Expression, and Enhances Astrocytes Antioxidation via the Cx43/Nrf2/HO-1 Axis[J]. Frontiers in Cell and Developmental Biology. 2020, 8: 302. Wu Y, Zeng S, Wan B, et al. Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis[J]. International Immunopharmacology. 2020: 107187. Chen X, Liang H, Xi Z, et al. BM-MSC Transplantation Alleviates Intracerebral Hemorrhage-Induced Brain Injury, Promotes Astrocytes Vimentin Expression, and Enhances Astrocytes Antioxidation via the Cx43/Nrf2/HO-1 Axis. Frontiers in Cell and Developmental Biology. 2020, 8: 302 Tao M, Yan W, Chen C, et al.Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.Life Sciences.2023: 121847. Fan P, Lu Y, Wei H, et al.Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.Metabolic Brain Disease.2023: 1-17. Liu Y, Hou M, Pan Z, et al. Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression. Journal of Nanobiotechnology. 2022, 20(1): 1-20 Zhang L, Hu C, Jin B, et al.Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.Cardiovascular Drugs and Therapy.2023: 1-14. Chen F, Zhu J, Wang W. Ulinastatin Attenuates LPS-Induced Inflammation and Inhibits Endoplasmic Reticulum Stress?Induced Apoptosis in Renal Tubular Epithelial Cells via Regulation of the TLR4/NF-?B and Nrf2/HO-1 Pathways. Inflammation. 2021: 1-10. Xinnong Liu, et al. Isoliquiritigenin ameliorates acute pancreatitis in mice via inhibition of oxidative stress and modulation of the Nrf2/HO-1 pathway. Oxid Med Cell Longev. 20 March 2018. Wu Y, Zeng S, Wan B, et al. Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis. International Immunopharmacology. 2021, 90: 107187 Wu Y, Zeng S, Wan B, et al. Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis[J]. International Immunopharmacology. 2021, 90: 107187 Chen Z, Wang H, Hu B, et al. Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function. European Journal of Histochemistry. 2022, 66(3) Lin Y, Luo T, Weng A, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling[J]. Frontiers in Immunology. 2020, 11: 3197. Singh A, et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol. 2016 Nov 18;11(11):3214-3225. Zheng W, Yang H, Lin H, et al.ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis.Molecular & Cellular Toxicology.2023: 1-10. Jin B, Chen Y, Wang J, et al.Costunolide alleviates hyperglycaemia?induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.Journal of Cellular and Molecular Medicine.2023 Wang N, Nie H, Zhang Y, et al. Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway. Inflammation Research. 2021: 1-14. Chen Y, Shi J, Wang X, et al.An antioxidant feedforward cycle coordinated by linker histone variant H1. 2 and NRF2 that drives nonsmall cell lung cancer progression.Proceedings of the National Academy of Sciences.2023, 120(39): e2306288120. Cao L, Zhao J, Ma L, et al. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor signaling pathway. Ecotoxicology and Environmental Safety. 2021, 225: 112737. Jiang H, Lin C, Cai T, et al.Taxifolin?mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid?induced osteonecrosis of the femoral head.Phytotherapy Research.2023 Zhang H, Chen C, Liu Y, et al. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules. Oxidative Medicine and Cellular Longevity. 2022