TargetMol

CEP-40783

Product Code:
 
TAR-T4426
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4426-1mg1mg£95.00
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TAR-T4426-5mg5mg£128.00
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TAR-T4426-1mL1 mL * 10 mM (in DMSO)£151.00
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TAR-T4426-10mg10mg£168.00
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TAR-T4426-25mg25mg£302.00
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TAR-T4426-50mg50mg£367.00
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TAR-T4426-100mg100mg£497.00
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TAR-T4426-200mg200mg£687.00
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Further Information

Bioactivity:
CEP-40783 is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
CAS:
1437321-24-8
Formula:
C31H26F2N4O6
Molecular Weight:
588.568
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9964
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC
Target:
c-Met/HGFR; TAM Receptor

References

Miknyoczki S, Cheng M, Hudkins R, et al. Abstract C275: CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers.[J]. Molecular Cancer Therapeutics, 2013, 12(11_Supplement):C275-C275. Franovic A, Schairer A E, Uryu S, et al. 65 ? RXDX-106 Is an orally-available, potent and selective TAM/MET inhibitor demonstrating preClinicalal efficacy in MET-dependent human malignancies[J]. European Journal of Cancer, 2016, 69:S28?S29.