Ralinepag

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TargetMol
Product Code: TAR-T4635
Supplier: TargetMol
CodeSizePrice
TAR-T4635-1mg1mg£115.00
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TAR-T4635-5mg5mg£177.00
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TAR-T4635-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T4635-10mg10mg£262.00
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TAR-T4635-25mg25mg£352.00
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TAR-T4635-50mg50mg£491.00
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TAR-T4635-100mg100mg£680.00
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TAR-T4635-500mg500mg£1,340.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Ralinepag is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
CAS:
1187856-49-0
Formula:
C23H26ClNO5
Molecular Weight:
431.91
Pathway:
GPCR/G Protein; ; Immunology/Inflammation
Purity:
0.9985
SMILES:
OC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1
Target:
Prostaglandin Receptor

References

Tran TA, et al. Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2017 Feb 9;60(3):913-927