2-Ketoglutaric acid Sodium
| Code | Size | Price |
|---|
| TAR-T4920-250mg | 250mg | £97.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4920-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
alpha-Ketoglutarate is a key molecule in the TCA cycle(PMID: 26759695 ). It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.
CAS:
22202-68-2
Formula:
C5H5NaO5
Molecular Weight:
168.08
Pathway:
Metabolism; Proteases/Proteasome
Purity:
0.98
SMILES:
[Na+].OC(=O)CCC(=O)C([O-])=O
Target:
Tyrosinase; Endogenous Metabolite
References
Chin RM, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19;510(7505):397-401.
Klysz D, et al. Glutamine-dependent ?-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation. Sci Signal. 2015 Sep 29;8(396):ra97.
Wu N, et al. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016 Jan;24(1):1-8.