SR3335

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TargetMol
Product Code: TAR-T5160
Supplier: TargetMol
CodeSizePrice
TAR-T5160-1mg1mg£95.00
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TAR-T5160-5mg5mg£128.00
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TAR-T5160-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T5160-10mg10mg£173.00
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TAR-T5160-25mg25mg£278.00
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TAR-T5160-50mg50mg£454.00
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TAR-T5160-100mg100mg£624.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
CAS:
293753-05-6
Formula:
C13H9F6NO3S2
Molecular Weight:
405.33
Pathway:
Metabolism
Purity:
0.9941
SMILES:
OC(c1ccc(NS(=O)(=O)c2cccs2)cc1)(C(F)(F)F)C(F)(F)F
Target:
ROR

References

Sadeghi H, et al. The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita. J Pathol. 2015 Sep;237(1):111-22. Kumar N, et al. Identification of SR3335 (ML-176): a synthetic ROR? selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22.